Browsing by Author "Apidianakis, Yiorgos"
Now showing items 1-20 of 44
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Article
The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies
Kapsetaki, Stefania Elisavet; Tzelepis, Ilias; Avgousti, Kalodoti; Livadaras, Ioannis; Garantonakis, Nikos G.; Varikou, Kyriaki N.; Apidianakis, Yiorgos (2014)Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the 'grape-like' odorant 2-aminoacetophenone (2AA), secreted by ...
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Article
Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response
Apidianakis, Yiorgos; Rahme, L. G.; Heitman, J.; Ausubel, F. M.; Calderwood, S. B.; Mylonakis, E. (2004)We found that the ingestion of Cryptococcus neoformans by Drosophila melanogaster resulted in the death of the fly but that the ingestion of Saccharomyces cerevisiae or the nonpathogenic Cryptococcus kuetzingii or Cryptococcus ...
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Article
Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
Panagi, Myrofora; Georgila, Konstantina; Eliopoulos, Aristides G.; Apidianakis, Yiorgos (2019)https://doi.org/10.18632/oncotarget.6463 Myrofora Panagi, Konstantina Georgila, Aristides G. Eliopoulos, Yiorgos Apidianakis
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Conference Object
Diet-dependent compatition between Pseudomonas aeruginosa and Escherichea coli in the host intestine
Apidianakis, Yiorgos (Fondation Santé, 2019)
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Article
Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection
Apidianakis, Yiorgos; Que, Y. -A; Xu, W.; Tegos, G. P.; Zimniak, P.; Hamblin, M. R.; Tompkins, R. G.; Xiao, W.; Rahme, L. G. (2012)Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...
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Article
Drosophila and the hallmarks of cancer
Christofi, T.; Apidianakis, Yiorgos (2013): Cancer was the disease of the twentieth century. Today it is still a leading cause of death worldwide despite being intensively investigated. Abundant knowledge exists regarding the pathological and molecular mechanisms ...
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Article
Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity
Apidianakis, Yiorgos; Christofi, T. (2013)Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila ...
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Article
Drosophila melanogaster as a model for human intestinal infection and pathology
Apidianakis, Yiorgos; Rahme, L. G. (2011)Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...
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Article
Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection
Apidianakis, Yiorgos; Rahme, L. G. (2009)Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...
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Book Chapter
Drosophila melanogaster as a versatile model for the discovery of drugs effective against human Microbe-induced infection and pathology
Apidianakis, Yiorgos; Kontoyiannis, D. P. (CABI Publishing, 2012)
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Article
Drosophila melanogaster: A first step and a stepping-stone to anti-infectives
Tzelepis, Ilias; Kapsetaki, Stefania Elisavet; Panayidou, S.; Apidianakis, Yiorgos (2013)Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. Traditionally, chemical libraries are screened either using in vitro ...
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Article
Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila
Ligoxygakis, P.; Bray, S. J.; Apidianakis, Yiorgos; Delidakis, Christos (1999)A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors. ...
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Article
Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch
Apidianakis, Yiorgos; Grbavec, D.; Stifani, S.; Delidakis, Christos (2001)Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...
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Article
Hedgehog restricts its expression domain in the Drosophila wing
Bejarano, F.; Pérez, L.; Apidianakis, Yiorgos; Delidakis, Christos; Milán, M. (2007)The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...
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Article
A holo'ome approach in colon cancer: We change as we age
Apidianakis, Yiorgos; Eliopoulos, Aristides G. (2015)
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Article
Homeostasis in Infected Epithelia: Stem Cells Take the Lead
Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...
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Article
Homeostatic interplay between bacterial cell-cell signaling and iron in virulence
Hazan, R.; He, J.; Xiao, G.; Dekimpe, V.; Apidianakis, Yiorgos; Lesic, B.; Astrakas, C.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2010)Pathogenic bacteria use interconnected multi-layered regulatory networks, such as quorum sensing (QS) networks to sense and respond to environmental cues and external and internal bacterial cell signals, and thereby adapt ...
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Article
Human pathogenic bacteria, fungi, and viruses in Drosophila
Panayidou, S.; Ioannidou, E.; Apidianakis, Yiorgos (2014)Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, ...
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Article
Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells
Bangi, E.; Pitsouli, Chrysoula; Rahme, L. G.; Cagan, R.; Apidianakis, Yiorgos (2012)Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...
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Article
In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury
Constantinou, Constantina; Apidianakis, Yiorgos; Psychogios, N.; Righi, V.; Mindrinos, M. N.; Khan, N.; Swartz, H. M.; Szeto, H. H.; Tompkins, R. G.; Rahme, L. G.; Aria Tzika, A. (2016)Trauma is the most common cause of mortality among individuals aged between 1 and 44 years and the third leading cause of mortality overall in the US. In this study, we examined the effects of trauma on the expression of ...